|Application ||WB, IHC-P, FC, E|
|Calculated MW||76890 Da|
|Antigen Region||116-143 aa|
|Other Names||Cirhin, CIRH1A, KIAA1988, UTP4|
|Target/Specificity||This CIRH1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 amino acids from the N-terminal region of human CIRH1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CIRH1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).|
|Cellular Location||Nucleus, nucleolus. Chromosome. Note=Found predominantly at the fibrillar center.|
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Provided below are standard protocols that you may find useful for product applications.
CIRH1A encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence.
Yu, B., et al. Exp. Cell Res. 315(18):3086-3098(2009) Carlton, V.E., et al. Ann. Med. 36(8):606-617(2004)
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