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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   DLL4 Antibody (C-term)   

DLL4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DLL4 Antibody (C-term) AP9964a
    Western blot analysis of DLL4 Antibody (C-term) (Cat. #AP9964a) in K562 cell line lysates (35ug/lane). DLL4 (arrow) was detected using the purified Pab.
  • IHC-P - DLL4 Antibody (C-term) AP9964a
    DLL4 Antibody (C-term) (Cat. #AP9964a) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DLL4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - DLL4 Antibody (C-term) AP9964a
    DLL4 Antibody (C-term) (Cat. #AP9964a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q9NR61
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 74605 Da
Antigen Region 625-652 aa
Additional Information
Gene ID 54567
Other Names Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
Target/Specificity This DLL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 625-652 amino acids from the C-terminal region of human DLL4.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDLL4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLL4
Function Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in vascular endothelium.
Research Areas
Citations ( 0 )

Background

DLL4 is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

References

Emuss, V., et al. PLoS Pathog. 5 (10), E1000616 (2009)
Ferrari-Toninelli, G., et al. Dev Neurobiol 69(6):378-391(2009)
Indraccolo, S., et al. Cancer Res. 69(4):1314-1323(2009)
Segarra, M., et al. Blood 112(5):1904-1911(2008)

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Discontinued
Cat# AP9964a
Size:
(40 western blots)
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