|Application ||WB, IHC-P, FC, E|
|Calculated MW||40556 Da|
|Antigen Region||303-331 aa|
|Other Names||Sulfatase-modifying factor 1, 1899-, C-alpha-formylglycine-generating enzyme 1, SUMF1, FGE|
|Target/Specificity||This SUMF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the C-terminal region of human SUMF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SUMF1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SUMF1 encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine.
Oshikawa, M., et al. Mol. Vis. 15, 482-494 (2009)
Fraldi, A., et al. Hum. Mol. Genet. 17(17):2610-2621(2008)
Hara, K., et al. Neurology 71(8):547-551(2008)
Yis, U., et al. Brain Dev. 30(5):374-377(2008)
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