|Application ||WB, IHC-P, FC, E|
|Calculated MW||40556 Da|
|Antigen Region||303-331 aa|
|Other Names||Sulfatase-modifying factor 1, 1899-, C-alpha-formylglycine-generating enzyme 1, SUMF1, FGE|
|Target/Specificity||This SUMF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the C-terminal region of human SUMF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SUMF1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Ubiquitous. Highly expressed in kidney, pancreas and liver. Detected at lower levels in leukocytes, lung, placenta, small intestine, skeletal muscle and heart|
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Provided below are standard protocols that you may find useful for product applications.
SUMF1 encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine.
Oshikawa, M., et al. Mol. Vis. 15, 482-494 (2009)
Fraldi, A., et al. Hum. Mol. Genet. 17(17):2610-2621(2008)
Hara, K., et al. Neurology 71(8):547-551(2008)
Yis, U., et al. Brain Dev. 30(5):374-377(2008)
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