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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MRAP Antibody (N-term)   

MRAP Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MRAP Antibody (N-term) AP9980a
    Western blot analysis of MRAP Antibody (N-term) (Cat. #AP9980a) in 293 cell line lysates (35ug/lane). MRAP (arrow) was detected using the purified Pab.
  • IHC-P - MRAP Antibody (N-term) AP9980a
    MRAP Antibody (N-term) (Cat. #AP9980a) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MRAP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - MRAP Antibody (N-term) AP9980a
    MRAP Antibody (N-term) (Cat. #AP9980a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TCY5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 19136 Da
Antigen Region 7-36 aa
Additional Information
Gene ID 56246
Other Names Melanocortin-2 receptor accessory protein, B27, Fat cell-specific low molecular weight protein, Fat tissue-specific low MW protein, MRAP, C21orf61, FALP
Target/Specificity This MRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human MRAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMRAP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C21orf61, FALP
Function Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
Cellular Location Cell membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771) Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm
Tissue Location Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues
Research Areas
Citations (0)

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MRAP encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2.


Dias, R.P., et al. Eur. J. Endocrinol. 162(2):357-359(2010)
Chan, L.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(15):6146-6151(2009)
Webb, T.R., et al. Endocrinology 150(2):720-726(2009)

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$ 295.00
$ 99.00
Cat# AP9980a
(40 western blots)
Availability: In Stock
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