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NAL11 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP9991a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP9991a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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NAL11 Antibody (Center) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P59045 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 117779 Da |
NAL11 Antibody (Center) - Additional info | |
| Gene ID 204801 | |
| Other Names NLRP11; NALP11; NOD17; PAN10; PYPAF6; NACHT, LRR and PYD domains-containing protein 11; Nucleotide-binding oligomerization domain protein 17; PAAD-and NACHT domain-containing protein 10; PYRIN-containing APAF1-like protein 6 | |
| Target/Specificity This NAL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467~497 amino acids from the Central region of human NAL11. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NAL11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NAL11 Antibody (Center) - Protein Information | |
| Name NLRP11 | |
| Synonyms NALP11, NOD17, PAN10, PYPAF6 | |
| Function Involved in inflammation (Potential). | |
NAL11 Antibody (Center) - Related products
NAL11 Antibody (Center) - Application data
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Western blot analysis of NAL11 Antibody (Center) (Cat. #AP9991a) in HL-60 cell line lysates (35ug/lane). NAL11 (arrow) was detected using the purified Pab.
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NAL11 Antibody (Center) (Cat. #AP9991a) IHC analysis in formalin fixed and paraffin embedded tonsil followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the NAL11 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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NAL11 Antibody (Center) (Cat. #AP9991a) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
NAL11 Antibody (Center) - Research Areas
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BACKGROUND
NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
REFERENCES
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009) Enjuanes, A., et al. Cancer Res. 68(24):10178-10186(2008) Dowds, T.A., et al. Biochem. Biophys. Res. Commun. 302(3):575-580(2003)
