|Application ||WB, IHC-P, FC, E|
|Calculated MW||19718 Da|
|Antigen Region||81-109 aa|
|Other Names||Mitochondrial inner membrane protease subunit 2, 3421-, IMP2-like protein, IMMP2L|
|Target/Specificity||This IMP2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the Central region of human IMP2L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IMP2L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein|
|Tissue Location||Expressed in all tissues tested except adult liver and lung.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
IMP2L complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 (IMMP1L; MIM 612323) and IMP2 are the catalytic subunits of the IMP complex.
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
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