|Application ||WB, IHC-P, FC, E|
|Calculated MW||67943 Da|
|Antigen Region||192-220 aa|
|Other Names||Phostensin, Protein phosphatase 1 F-actin cytoskeleton-targeting subunit, Protein phosphatase 1 regulatory subunit 18, PPP1R18, HKMT1098, KIAA1949|
|Target/Specificity||This PHTNS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the N-terminal region of human PHTNS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PHTNS Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton.|
|Cellular Location||Isoform 1: Cytoplasm, cytoskeleton|
|Tissue Location||Isoform 4 is predominantly expressed in leukocytes and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
PHTNS interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin cytoskeleton。
Lai, N.S., et al. Biochem. Biophys. Res. Commun. 387(4):676-681(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009)
Kao, S.C., et al. Biochem. Biophys. Res. Commun. 356(3):594-598(2007)
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