|Application ||WB, EIA|
|Immunogen||Natural RCA60, full-length.|
|Purification||>95% pure (SDS-PAGE). Protein G Chromatography|
|Target/Specificity||Recognizes the A-chain of RCA60. Also recognizes RCA120. Ricin is a- cytotoxic lectin1possessing antitumor activity against various sarcomas in rat and mouse2. It is composed of an A and a B polypeptide chain (Mr approx. 30,000 each) joined by a disulphide bond. The B-chain has two sites that both bind galactosides and galactosaminides 34, and binds to the membrane of sensitive mammalian cells. Once the ricin has entered the cell, the A-chain specifically inhibits protein synthesis by decreasing the affinity of the 60 S ribosomal subunit for the elongation factors5.|
|Preservative||0.1% Sodium Azide|
|Storage||Store at 2-8°C.|
|Precautions||Monoclonal Antibody to Ricin, Ricinus communis agglutinin 60 (RCA60). [CP75] is for research use only and not for use in diagnostic or therapeutic procedures.|
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