|Immunogen||FK-506 BSA Conjugate|
|Purification||Euglobulin Precipitation and Dialysis|
|Target/Specificity||Detects FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. It is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis. FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogenic organ transplantation to reduce organ rejection.|
|Preservative||0.09% Sodium Azide|
|Storage||Short term store at 2-8°C. Long term aliquot and store at -20°C. Prepare working dilution only prior to immediate use. Avoid multiple freeze/thaw cycles.|
|Precautions||Monoclonal Antibody to Tacrolimus (FK-506) [B246M] is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The reference listed below is for research purposes only:Letko, E., et al., (1999), “Tacrolimus (FK506)”, Ann. Allergy Asthma Immunol., 83: 179-189.
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