|Application ||WB, IHC, E, DB|
|Other Names||Cell division protein kinase 4; Cyclin-dependent kinase 4; PSK-J3; CDK4|
|Reconstitution & Storage||Store at -20°C. Avoid freeze / thaw cycles. Short term storage +2°C-+8°C|
|Precautions||CYCLIN-DEPENDENT KINASE 4 (CDK4) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Cyclin-dependent kinase 4 combines with the protein cyclin D to form a protein complex that promotes the passage of cells through the G1 checkpoint in the cell growth cycle. This cellular activity is regulated by the protein p16 produced by p16INK4a. Normally, p16 controls cell growth by inhibiting the activity of the CDK4 cyclin D complex and stopping cells at the G1 checkpoint. RANDOX recombinant human CDK4 is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
Wƒ?lfel T. et al. (1995) Science 269: 1281-84.
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