|Application ||WB, IHC, E, DB|
|Other Names||CK-18; Cytokeratin-18; Keratin, type I cytoskeletal 18; Keratin-18; K18; Cell proliferation-inducing gene 46 protein; KRT18; CYK19|
|Reconstitution & Storage||Store at -20°C. Avoid freeze / thaw cycles. Short term storage +2°C-+8°C|
|Precautions||CYTOKERATIN-18 (CK18) Affinity Purified Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Tissue polypeptide specific antigen was first identified as a tumour marker in the late 1950's, and has recently been shown to be closely related to human cytokeratin 18. Cytokeratins are a group of about 20 cytoskeletal proteins, whose degradation gives rise to soluble fragments, measurable in the blood of patients. Serum levels are high in breast cancer patients and also some other malignancies, probably due to high cell turnover in tumours. RANDOX recombinant human CK-18 is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use
D'Alessandro, R. et al. (2001) Breast Cancer Res. Treat. 68(1): 9-19.
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