|Application ||WB, IHC, E, DB|
|Other Names||IL-12A; IL-12 subunit p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35 IL12P35Anti Interleukin-12p35 (IL12p35)IL12A|
|Reconstitution & Storage||Store at -20°C. Avoid freeze / thaw cycles. Short term storage +2°C-+8°C|
|Precautions||Interleukin-12p35 (IL12p35) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Active IL-12 is a p70 disulphide-linked dimer composed of p35 and p40 subunits. The protein is a pleiotropic cytokine produced primarily by antigen presenting cells and has multiple effects on T lymphocytes and natural killer cells in terms of stimulating cytotoxicity, proliferation, production of other cytokines and Th1 subset differentiation. RANDOX recombinant Interleukin-12p35 comprises a 197 amino acid fragment (57-253) corresponding to the mature Interleukin-12p35 chain protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
Gately, M.K. et al. (1998) Annual Rev. Immunol. 16 : 495- 521.
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