|Application ||WB, IHC, E, DB|
|Other Names||IL-12B; IL-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; NK cell stimulatory factor chain 2; NKSF2 NKSF2Interleukin-12p40 (IL12p40)IL12B|
|Reconstitution & Storage||Store at -20°C. Avoid freeze / thaw cycles. Short term storage +2°C-+8°C|
|Precautions||Interleukin-12p40 (IL12p40) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Active IL-12 is a p70 disulphide-linked dimer composed of p35 and p40 subunits. The protein is a pleiotropic cytokine produced primarily by antigen presenting cells and has multiple effects on T lymphocytes and natural killer cells in terms of stimulating cytotoxicity, proliferation, production of other cytokines and Th1 subset differentiation. RANDOX recombinant Interleukin-12p40 comprises a 306 amino acid fragment (23-328) corresponding to the mature Interleukin-12p40 chain protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
Gately, M.K. et al. (1998) Annual Rev. Immunol. 16 : 495- 522
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