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Purified Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E, DB |
|---|---|
| Host | Sheep |
| Clonality | Polyclonal |
| Other Names | PLANH1; Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; PAIE; Clade E; PLANH1; SERPINE 2 |
|---|---|
| Reconstitution & Storage | Store at -20°C. Avoid freeze / thaw cycles. Short term storage +2°C-+8°C |
| Precautions | PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) Affinity Purified Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PAI-1 is a serine protease inhibitor, which can exist either in an active inhibitory conformation or in an inactive or latent conformation. PAI-1 is produced mainly by the endothelium but is also secreted by other tissue types including adipose tissue. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1 have been linked with various conditions including cardiovascular disease, thrombosis, insulin resistance and obesity. RANDOX recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use
References
Gils, A & Declerck, P.J. 2004 Curr. Med. Chem. 11 (17) : 2323- 2334.
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