|Application ||WB, IHC, E, DB|
|Other Names||Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide; PDGF-1; PDGF subunit A; PDGFA; PDGF1; Platelet-derived growth factor subunit A|
|Reconstitution & Storage||Store at -20°C. Avoid freeze / thaw cycles. Short term storage +2°C-+8°C|
|Precautions||PLATELET-DERIVED GROWTH FACTOR A CHAIN (PDGF-A) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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The term PDGF refers to a family of disulphide bondlinked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist a short form that is soluble and a long form that is retained by the extracellular matrix. RANDOX recombinant PDGF-A comprises a 110 amino acid fragment (87-196) corresponding to the mature PDGF-A short chain protein and is expressed in E. coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use
Raines, E.W. & Ross, R. (1982) J. Biol. Chem. 257(9) : 5154-5160. Bonthron, D.T. et al. (1988). Proc. Natl. Acad. Sci USA 85(5): 1492-1496.
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