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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Neurturin Antibody   

Neurturin Antibody

     
  • IF - Neurturin Antibody ASC10012
    Immunofluorescence of TOLLIP in human brain tissue with TOLLIP antibody at 20 µg/ml.
  • IHC - Neurturin Antibody ASC10012
    Immunohistochemistry of SMARCA4 in mouse testis tissue with SMARCA4 antibody at 2 µg/ml.
  • WB - Neurturin Antibody ASC10012
    Western blot analysis of SAPAP2 in Raji cell lysate with SAPAP2 antibody at (A) 0.5 and (B) 1 µg/mL.
  • WB - Neurturin Antibody ASC10012
    Western blot analysis of TRPV4 in (A) human testis tissue and (B) SK-N-SH cell lysate with TRPV4 antibody at 1 µg/mL.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q99748
Other Accession NP_004549, 4902
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 14 kDa
Application Notes Neurturin antibody can be used for detection of neurturin by Western blot. An approximate 14 kDa band of the full length recombinant NTN was detected. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
Additional Information
Gene ID 4902
Other Names Neurturin Antibody: NTN, Neurturin, neurturin
Target/Specificity Neurturin antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Neurturin.

The immunogen is located within the last 50 amino acids of Neurturin.
Reconstitution & Storage Neurturin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNeurturin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NRTN
Function Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

Neurturin Antibody: Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFRβ, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRα-2 recently. NTN binds to and forms a complex with GFRα-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.

References

Kotzbauer PT, Lampe PA, Heuckeroth RO, et al. Neurturin, a relative glial-cell-line-derived neurotrophic factor. Nature 1996;384:467-470
Heuckeroth RO, Kotzbauer P, Copeland NG, et al. Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. Genomics 1997;44(1):137-40
Klein RD, Sherman D, Ho WH, et al. GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature 1997;387:717-721
Buj-Bello A, Adu J, Pinon LG, et al. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature 1997;387:721-724

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$ 320.00
Cat# ASC10012
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