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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL-1RAcP Antibody   

IL-1RAcP Antibody

  • WB - IL-1RAcP Antibody ASC10067
    Western blot analysis of IL-1RAcP in HeLa whole cell lysate with IL-1RAcP antibody at 1 µg/ml.
  • ICC - IL-1RAcP Antibody ASC10067
    Immunocytochemistry of IL-1RAcP in HeLa cells with IL-1RAcP antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NPH3
Other Accession NP_002173, 2599126
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 63 kDa

Observed: 63 kDa
Application Notes IL-1RAcP antibody can be used for detection of IL-1RAcP by Western blot 0.5 µg/mL. Antibody can also be used for immunocytochemistry starting at 5 µg/mL.
Additional Information
Gene ID 3556
Other Names IL-1RAcP Antibody: IL1R3, C3orf13, IL-1RAcP, IL1R3, Interleukin-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1 receptor accessory protein, interleukin 1 receptor accessory protein
Target/Specificity IL1RAP; It has no cross activity to other member in the IL-1 receptor family.
Reconstitution & Storage IL-1RAcP antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsIL-1RAcP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C3orf13, IL1R3
Function Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.
Tissue Location Detected in liver, skin, placenta, thymus and lung.
Research Areas
Citations (0)

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IL-1RAcP Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κB inducing kinae (NIK) and of NF-κB, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.


Greenfeder SA, Nunes P, Kwee L, et al. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 1995;270:13757-65.
Huang J, Gao X, Li S, et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 1997; 94:12829-32.
Wesche H, Korherr C, Kracht M, et al. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J. Biol. Chem. 1997;272:7727-31.
Hofmeister R, Wiegmann K, Korherr C, et al. Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein. J. Biol. Chem. 1997; 272:27730-6.

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$ 310.00
Cat# ASC10067
(40 western blots)
Availability: 5-7days
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