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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IRAK-2 Antibody   

IRAK-2 Antibody

  • WB - IRAK-2 Antibody ASC10083
    Western blot analysis of IRAK2 in K562 whole cell lysate with IRAK2 antibody at 1:500 dilution.
  • IF - IRAK-2 Antibody ASC10083
    Immunofluorescence of IRAK2 in HeLa cells with IRAK antibody at 10 µg/mL.
  • IF - IRAK-2 Antibody ASC10083
    Immunofluorescence of IRAK-2 in Hela cells with IRAK-2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43187
Other Accession AF026273, 2653876
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 65 kDa
Application Notes IRAK-2 antibody can be used for detection of IRAK2 by Western blot 0.5 µg/mL. A 65 kDa band can be detected. Antibody can also be used for immunoflourescence starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 3656
Other Names IRAK-2 Antibody: IRAK-2, Interleukin-1 receptor-associated kinase-like 2, IRAK-2, interleukin-1 receptor-associated kinase 2
Target/Specificity IRAK2; Anti-IRAK2 has no cross response to IRAK.
Reconstitution & Storage IRAK-2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsIRAK-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRAK2
Function Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Tissue Location Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
Research Areas
Citations (0)

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IRAK-2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κB activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-κB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.


Cao Z; Henzel WJ; Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 1996;271:1128-31.
Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997;278:1612-5
Zhang FX, Kirschning CJ, Mancinelli R, Xu XP, Jin Y, Faure E, Mantovani A, Rothe M, Muzio M, Arditi M. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 1999;274:7611-4
Yang RB, Mark MR, Gurney AL , Godowski PJ. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J Immunol 1999;163:639-43 (RD0300)

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$ 310.00
Cat# ASC10083
(40 western blots)
Availability: 5-7days
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