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Ski Antibody

  • WB - Ski Antibody ASC10101
    Western blot analysis of Ski in HeLa cell lysate with Ski antibody at (A) 1 and (B) 2 µg/mL.
  • IF - Ski Antibody ASC10101
    Immunofluorescence of Ski in human kidney tissue with Ski antibody at 20 µg/mL.
  • IF - Ski Antibody ASC10101
    Immunofluorescence of Ski in Human Kidney cells with Ski antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12755
Other Accession P12755, 134517
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 80005 Da
Application Notes SkiP antibody can be used for detection of Ski by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 20 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 6497
Other Names Ski Antibody: SGS, SKV, Ski oncogene, Proto-oncogene c-Ski, v-ski sarcoma viral oncogene homolog (avian)
Target/Specificity SKI;
Reconstitution & Storage Ski antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSki Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SKI
Function May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Ski Antibody: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.


Derynck R, Akhurst RJ, and Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 2001; 29:117-129.
Li Y, Turck CM, Teumer JK, et al. Unique sequence, ski, in Sloan-Kettering avian retrovirus with properties of a new cell-derived oncogene. J. Virol. 1986; 57:1065-72.
Luo K. Ski and SnoN: negative regulators of TGF-β signaling. Curr. Op. Gen. Dev. 2004; 14:65-70.
Massague J and Wotton D. Transcriptional control by the TGF-b/Smad signaling system. EMBO J. 2000; 19:1745-54.

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$ 310.00
Cat# ASC10101
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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