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TP1 Antibody

  • WB - TP1 Antibody ASC10123
    Western blot analysis of TP1 in human kidney tissue lysate with TP1 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - TP1 Antibody ASC10123
    Immunohistochemical staining of human lung tissue using TP1 antibody at 2.5 µg/mL.
  • IF - TP1 Antibody ASC10123
    Immunofluorescence of TP-1 in Human Lung cells with TP-1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99973
Other Accession AAC51107, 1848277
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 290490 Da
Application Notes TP1 antibody can be used for detection of TP1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 7011
Other Names TP1 Antibody: TP1, TLP1, p240, TROVE1, VAULT2, TP1, Telomerase protein component 1, Telomerase-associated protein 1, Telomerase protein 1, telomerase-associated protein 1
Target/Specificity TEP1;
Reconstitution & Storage TP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TEP1
Synonyms TLP1, TP1
Function Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).
Cellular Location Nucleus. Chromosome, telomere.
Tissue Location Ubiquitous..
Citations (0)

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TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.


Greider CW. Telomere length regulation. Annu. Rev. Biochem.1996; 274:92-7.
Cong YS, Wright WE, and Shay JW. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev.2002; 66:407-25.
Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science1997; 275:973-7.
Wong JMY and Collins K. Telomere maintenance and disease. Lancet2003; 362:983-8.

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$ 310.00
Cat# ASC10123
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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