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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   APRIL Antibody   

APRIL Antibody

  • WB - APRIL Antibody ASC10135
    Western blot analysis of APRIL expression in Jurkat cells with APRIL antibody at 1 µg/mL (A), 2 µg/mL (B), and 4 µg/mL (C).
  • IHC - APRIL Antibody ASC10135
    Immunohistochemistry of APRIL in human prostate tissue with APRIL antibody at 10 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75888
Other Accession NP_003799, 4507599
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 27 kDa

Observed: 27 kDa
Application Notes APRIL antibody can be used for detection of APRIL by Western blot at 1 - 4 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL.
Additional Information
Gene ID 8741
Other Names APRIL Antibody: APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715, APRIL, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, tumor necrosis factor (ligand) superfamily, member 13
Target/Specificity TNFSF13;
Reconstitution & Storage APRIL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsAPRIL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFSF13
Synonyms APRIL, TALL2, ZTNF2
Function Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
Cellular Location Secreted.
Tissue Location Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages
Research Areas
Citations (0)

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APRIL Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1α (for TNF related death ligand 1α) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.


Hahne M, Kataoka T, Schroter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 1998; 188:1185-90.
Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 1999; 65:680-3.
Kelly K, Manos E, Jensen G, et al. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000; 60:1021-7.
Yu G, Boone T, Delaney J, et al. APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 2000; 1:252-6.

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$ 310.00
Cat# ASC10135
(40 western blots)
Availability: 5-7days
Bulk Size
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