|Application ||WB, IF, E|
|Other Accession||NP_068570, 50615|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||60 kDa|
|Application Notes||IL-21 receptor antibody can be used for detection of IL-21 receptor by Western blot at 1 μg/mL. An approximately 60 kDa band can be detected. For immunofluorescence start at 20 μg/mL.|
|Other Names||IL-21 Receptor Antibody: NILR, CD360, NILR, UNQ3121/PRO10273, Interleukin-21 receptor, Novel interleukin receptor, IL-21 receptor, interleukin 21 receptor|
|Target/Specificity||IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 20 to 32 of human IL-21 receptor precursor.|
The immunogen is located within the first 50 amino acids of IL-21 Receptor.
|Reconstitution & Storage||IL-21 Receptor antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||IL-21 Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for interleukin-21.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen|
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Provided below are standard protocols that you may find useful for product applications.
IL-21 Receptor Antibody: A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408(6808):57-63.
Ozaki K, Kikly K, Michalovich D, et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci USA. 2000;97(21):11439-44.
Asao H, Okuyama C, Kumaki S, et al. the common γ-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167(1):1-5.
Vosshenrich CA, Di Santo JP. Cytokines: IL-21 joins the γ(c)-dependent network Curr Biol. 2001;11(5):R175-7.
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