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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   MCG10 Antibody   

MCG10 Antibody

     
  • WB - MCG10 Antibody ASC10145
    Western blot analysis of MCG10 in HeLa cell lysate with MCG10 antibody at (A) 0.5, (B) 1 and (C) 2 µg/mL.
  • ICC - MCG10 Antibody ASC10145
    Immunocytochemistry of MCG10 in HeLa cells with MCG10 antibody at 1 µg/mL.
  • IF - MCG10 Antibody ASC10145
    Immunofluorescence of MCG10 in Hela cells with MCG10 antibody at 20 µg/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, ICC, E
Primary Accession P57723
Other Accession EAW65166, 119585570
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 41482 Da
Application Notes MCG10 antibody can be used for detection of MCG10 by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 57060
Other Names MCG10 Antibody: CBP, LIP4, MCG10Alpha-CP4, poly(rC) binding protein 4
Target/Specificity PCBP4;
Reconstitution & Storage MCG10 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsMCG10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCBP4
Function Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

MCG10 Antibody: MCG10 is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor. Multiple alternatively spliced isoforms of MCG10 have been identified.

References

Makeyev AV and Liebhaber SA. The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms. RNA2002; 8:265-78.
Zhu J and Chen X. MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G2-M. Mol. Cell Biol.2000; 20:5602-5618.
Pio R, Zudaire I, Pino I, et al. a-CP-4, encoded by a putative tumor suppressor gene at 3p21, but not its alternative splice variant aCP-4a, is underexpressed in lung cancer. Cancer Res.2004; 64:4171-9.

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$ 320.00
Cat# ASC10145
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