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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CIKS Antibody   

CIKS Antibody

  • WB - CIKS Antibody ASC10153
    Western blot analysis of CIKS expression in human placenta tissue lysate with CIKS antibody at 1 µg /ml.
  • IHC - CIKS Antibody ASC10153
    Immunohistochemistry of CIKS in human lung tissue with CIKS antibody at 5 µg/mL.
  • IF - CIKS Antibody ASC10153
    Immunofluorescence of CIKS in Human Lung cells with CIKS antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43734
Other Accession AF274303, 10242289
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 63 kDa
Application Notes CIKS antibody can be used for detection of CIKS by Western blot at 1 µg/mL. A band at approximately 63 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 10758
Other Names CIKS Antibody: ACT1, CIKS, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, PSORS13, Adapter protein CIKS, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3 interacting protein 2
Target/Specificity TRAF3IP2;
Reconstitution & Storage CIKS antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsCIKS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C6orf2, C6orf4, C6orf5, C6orf6
Function Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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CIKS Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB associates with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. IκB is phosphorylated by IκB kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-κB activator 1). CIKS directly interacts with IKKγ. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues.


Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U. CIKS, a connection to Iκ B kinase and stress-activated protein kinase. Proc Natl Acad Sci USA. 2000;97(19):10494-9.
Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark GR. Act1, an NF-κ B activating protein. Proc Natl Acad Sci USA. 2000;97(19):10489-93.

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$ 310.00
Cat# ASC10153
(40 western blots)
Availability: 5-7days
Bulk Size
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