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KLHL1 Antibody

  • WB - KLHL1 Antibody ASC10165
    Western blot analysis of KLHL1 in human brain cell lysate with KLHL1 antibody at (A) 2 and (B) 4 µg /ml.
  • IHC - KLHL1 Antibody ASC10165
    Immunohistochemistry of KLHL1 in rat brain tissue with KLHL1 antibody at 10 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NR64
Other Accession AAF81719, 8926179
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 82680 Da
Application Notes KLHL1 antibody can be used for the detection of KLHL1 by Western blot at 2 - 4 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL.
Additional Information
Gene ID 57626
Other Names KLHL1 Antibody: MRP2, KIAA1490, Kelch-like protein 1, kelch-like 1 (Drosophila)
Target/Specificity KLHL1;
Reconstitution & Storage KLHL1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsKLHL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KLHL1
Synonyms KIAA1490
Function May play a role in organizing the actin cytoskeleton of the brain cells.
Cellular Location Cytoplasm, cytoskeleton.
Tissue Location Highly expressed in brain.
Research Areas
Citations (0)

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KLHL1 Antibody: The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins. Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.


Nemes JP, Benzo KA, and Koob MD. The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). Human Mol. Gen. 2000; 9:1543-51.
Adams J, Kelso R, and Cooley L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 2000; 10:17-24.
Robinson DN and Cooley L. Drosophila kelch is an oligomeric ring canal actin organizer. J. Cell Biol. 1997; 138:799-810.

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$ 310.00
Cat# ASC10165
(40 western blots)
Availability: 5-7days
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