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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Bcl-rambo Antibody   

Bcl-rambo Antibody

  • WB - Bcl-rambo Antibody ASC10167
    Western blot analysis of Bcl-rambo in K562 cell lysate with Bcl-rambo antibody at (A) 2 and (B) 4 µg/mL.
  • IHC - Bcl-rambo Antibody ASC10167
    Immunohistochemistry of Bcl-rambo in human heart tissue with Bcl-rambo antibody at 10 µg/mL.
  • IF - Bcl-rambo Antibody ASC10167
    Immunofluorescence of Bcl-rambo in Human Heart cells with Bcl-rambo antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BXK5
Other Accession AAH07658, 14043326
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 52723 Da
Application Notes Bcl-rambo antibody can be used for the detection of Bcl-rambo by Western blot at 2 and 4 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 23786
Other Names Bcl-rambo Antibody: MIL1, BCL-RAMBO, Bcl2-L-13, MIL1, CD003, Bcl-2-like protein 13, Bcl-rambo, BCL2-like 13 (apoptosis facilitator)
Target/Specificity BCL2L13;
Reconstitution & Storage Bcl-rambo antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsBcl-rambo Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2L13
Synonyms MIL1
Function May promote the activation of caspase-3 and apoptosis.
Cellular Location Isoform 2: Mitochondrion membrane; Single-pass membrane protein. Nucleus
Tissue Location Ubiquitous, with the highest levels of expression in heart, placenta and pancreas
Research Areas
Citations (0)

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Bcl-rambo Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.


Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
Kataoka T, Holler N, Michau O, et al. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. J. Biol. Chem. 2001; 276:19548-54.,

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$ 310.00
Cat# ASC10167
(40 western blots)
Availability: 5-7days
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