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Caspase-12 Antibody (Large)

  • WB - Caspase-12 Antibody (Large) ASC10210
    Western blot analysis of caspase-12 in human heart lysate with caspase-12 antibody at (A) 0.5, (B) 1, and (C) 2 µg/mL, respectively.
  • IHC - Caspase-12 Antibody (Large) ASC10210
    Immunohistochemical staining of human heart tissue using caspase-12 antibody at 2 µg/mL.
  • IF - Caspase-12 Antibody (Large) ASC10210
    Immunofluorescence of Caspase-12 in Human Heart tissue with Caspase-12 antibody at 10 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O08736
Other Accession CAA73532, 2094806
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 46 kDa

Observed: 46 kDa
Application Notes Caspase-12 (large) antibody can be used for the detection of both the propeptide and cleaved forms of caspase-12 by Western blot at 0.5 to 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2 µg/mL. For immunofluorescence start at 10 µg/mL.
Additional Information
Gene ID 12364
Other Names Caspase-12 (Large) Antibody: Caspase-12, CASP-12, caspase 12
Target/Specificity Casp12; Caspase-12 (large) antibody is predicted to have no cross reactivity to other members in the caspase family.
Reconstitution & Storage Caspase-12 (Large) antibody can be stored at -20℃, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsCaspase-12 Antibody (Large) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp12
Function Involved in the activation cascade of caspases responsible for apoptosis execution.
Tissue Location Mainly expressed in skeletal muscle and lung.
Research Areas
Citations (0)

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Caspase-12 Antibody: (Large)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.


Nakagawa T, Zhu H, Morishima N, et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature 2000; 403:98-103.
Mehmet H. Caspases find a new place to hide. Nature 2000; 403:29-30
Van de Craen M, Vandenabeele P, Declercq W, et al. Characterization of seven murine caspase family members. FEBS Lett. 1997; 403:61-9

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$ 310.00
Cat# ASC10210
(40 western blots)
Availability: 5-7days
Bulk Size
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