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BOK Antibody

  • IHC - BOK Antibody ASC10257
    Immunohistochemistry of BOK in human brain tissue with BOK antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UMX3
Other Accession AAH06203, 14210524
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 23280 Da
Application Notes BOK antibody can be used for detection of BOK by immunohistochemistry at 5 µg/mL.
Additional Information
Gene ID 666
Other Names BOK Antibody: BOKL, BCL2L9, Bcl-2-related ovarian killer protein, Bcl-2-like protein 9, hBOK, BCL2-related ovarian killer
Target/Specificity BOK; At least three isoforms of BOK are known to exist; this antibody will not detect the smallest isoform. BOK antibody is predicted to not cross-react with other Bcl-2 protein family members
Reconstitution & Storage BOK antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsBOK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BOK
Synonyms BCL2L9
Function Induces apoptosis in a manner dependent on BAX and BAK.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=The transmembrane domain is necessary and sufficient for Golgi and ER targeting
Tissue Location Expressed in brain, liver, appendix and lymphoid tissues.
Research Areas
Citations (0)

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BOK Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. BOK, a pro-apoptotic Bcl-2 family member, was initially identified in the ovary, and was found to interact with other Bcl-2 family members such as Mcl-1 and Bfl-1. BOK expression is high during early placental development, suggesting that it may also play a role in regulating trophoblast cell proliferation.


Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
Hsu SY, Kaipia A, McGee E, et al. bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. USA 1997; 94:12401-6
Soleymanlou N, Wu Y, Wang JX, et al. A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. Cell Death Differ. 2005; 12:441-52.

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$ 310.00
Cat# ASC10257
(40 western blots)
Availability: 5-7days
Bulk Size
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