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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   WNV Core Antibody    

WNV Core Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06935
Other Accession NP_776011, 27735299
Reactivity Virus
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 380110 Da
Application Notes WNV Core antibody can be used for the detection of the WNV Core protein in ELISA. It will detect 10 ng of free peptide at 1 µg/mL.
Additional Information
Gene ID 912267
Other Names WNV Core Antibody : Genome polyprotein, Core protein, NS1, Anchored core protein C
Target/Specificity WNVgp1;
Reconstitution & Storage WNV Core antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsWNV Core Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity).
Cellular Location Capsid protein C: Virion. Host membrane; Single-pass membrane protein Envelope protein E: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane {ECO:0000255|PROSITE- ProRule:PRU00860}; Multi-pass membrane protein Non-structural protein 2A: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Multi- pass membrane protein Serine protease NS3: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Peripheral membrane protein {ECO:0000255|PROSITE- ProRule:PRU00860}; Cytoplasmic side {ECO:0000255|PROSITE- ProRule:PRU00860}. Note=Remains non-covalently associated to NS3 protease. {ECO:0000255|PROSITE-ProRule:PRU00860} Non-structural protein 4B: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Multi- pass membrane protein
Research Areas
Citations (0)

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WNV Core Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.


Gould LH and Fikrig E. West Nile virus: a growing concern. J. Clin. Invest. 2004; 113:1102-7.
Chu JJ, Rajamanonmani R, Li J, et al. Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein. J. Gen. Virol. 2005; 86:405-12.
Chu JJ and Ng ML. Interaction of West Nile virus with α v β 3 integrin mediates virus entry into cells. J. Biol. Chem. 2004; 279:54533-41.
Yang JS, Ramanathan MP, Muthumani K, et al. Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway. Emerg. Infect. Dis. 2002; 8:1379-84.

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$ 310.00
Cat# ASC10286
(40 western blots)
Availability: 5-7days
Bulk Size
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