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- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | P06935 |
| Other Accession | NP_776014, 27735302 |
| Reactivity | Virus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 380110 Da |
| Application Notes | West Nile virus envelope antibody can be used for the detection of the West Nile virus envelope protein in ELISA. It will detect 10 ng of free peptide at 1 µg/mL. |
| Gene ID | 912267 |
|---|---|
| Other Names | West Nile Virus Envelope Antibody: Genome polyprotein, Core protein, NS1, Envelope protein |
| Target/Specificity | WNVgp1; |
| Reconstitution & Storage | West Nile Virus Envelope antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | West Nile Virus Envelope Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POLG |
|---|---|
| Function | Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA. |
| Cellular Location | Capsid protein C: Virion. Host membrane; Single-pass membrane protein Envelope protein E: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane {ECO:0000255|PROSITE- ProRule:PRU00860}; Multi-pass membrane protein Non-structural protein 2A: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Multi- pass membrane protein Serine protease NS3: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Peripheral membrane protein {ECO:0000255|PROSITE- ProRule:PRU00860}; Cytoplasmic side {ECO:0000255|PROSITE- ProRule:PRU00860}. Note=Remains non-covalently associated to NS3 protease. {ECO:0000255|PROSITE-ProRule:PRU00860} Non-structural protein 4B: Host endoplasmic reticulum membrane {ECO:0000255|PROSITE-ProRule:PRU00860}; Multi- pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
West Nile Virus Envelope Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.
References
Gould LH and Fikrig E. West Nile virus: a growing concern.J. Clin. Invest. 2004; 113:1102-7.
Yang JS, Ramanathan MP, Muthumani K, et al. Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway. Emerg. Infect. Dis. 2002; 8:1379-84.
Chu JJ, Rajamanonmani R, Li J, et al. Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein. J. Gen. Virol. 2005; 86:405-12.
Chu JJ and Ng ML. Interaction of West Nile virus with α v β 3 integrin mediates virus entry into cells. J. Biol. Chem. 2004; 279:54533-41.
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