|Other Accession||P59596, 30173398|
|Calculated MW||25061 Da|
|Application Notes||SARS matrix antibody can be used for the detection of SARS matrix protein in ELISA. It will detect 10 ng of free peptide at 1 µg/mL.|
|Other Names||SARS Matrix Antibody: Membrane protein, E1 glycoprotein, M protein, Membrane protein|
|Reconstitution & Storage||SARS Matrix antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||SARS Matrix Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.|
|Cellular Location||Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein Note=Largely embedded in the lipid bilayer.|
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Provided below are standard protocols that you may find useful for product applications.
SARS Matrix Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. The M protein (Membrane protein, Matrix protein) is one of the major structural viral proteins. It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein and the nucleocapsid protein.
Marra MA, Jones SJ, Astell CR, et al. The Genome sequence of the SARS-associated corona virus. Science 2003;300:1399-404.
Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003;300:1394-9.
Navas-Nartin SR and Weiss S. Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. J Neurovirol. 2004;10:75-85.
Opstelten DJ, Raamsman MJ, Wolfs K, et al. Envelope glycoprotein interactions in coronavirus assembly. J Cell Biol. 1995;131:339-49.
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