|Application ||WB, IHC-P, E|
|Other Accession||NP_005736, 32171186|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||27992 Da|
|Application Notes||BAP31 antibody can be used for the detection of BAP31 by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2 µg/mL.|
|Other Names||BAP31 Antibody: CDM, DDCH, BAP31, 6C6-AG, DXS1357E, B-cell receptor-associated protein 31, 6C6-AG tumor-associated antigen, BCR-associated protein 31, B-cell receptor-associated protein 31|
|Reconstitution & Storage||BAP31 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||BAP31 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex|
|Tissue Location||Ubiquitous. Highly expressed in neurons and discrete endocrine cells.|
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Provided below are standard protocols that you may find useful for product applications.
BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.
Ng F, Nguyen M, Kwan T, et al. p28 BAP31, a Bcl-2/Bcl-XL- and procaspase-8-associated proteinin the endoplasmic reticulum. J. Cell Biol.1997; 139:327-38.
Kim KM, Adachi T, Nielsen PJ, et al. Two new proteins preferentially associated with membrane immunoglobulin D. EMBO J.1994; 13:3793-800.
Paquet M-E, Cohen-Doyle M, Shore GC, et al. Bap29/31 influences the intracellular traffic of MHC class I molecules. J. Immunol.2004; 172:7548-55.
Zen K, Utech M, Liu Y, et al. Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils. J. Biol. Chem.2004; 279:44924-30.
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