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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNFRSF14 Antibody   

TNFRSF14 Antibody

  • WB - TNFRSF14 Antibody ASC10410
    Western blot analysis of TNFRSF14 in mouse thymus tissue lysate with TNFRSF14 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - TNFRSF14 Antibody ASC10410
    Immunohistochemistry of TNFRSF14 in mouse thymus tissue with TNFRSF14 antibody at 1 µg/mL.
  • IF - TNFRSF14 Antibody ASC10410
    Immunofluorescence of TNFRSF14 in Mouse Thymus tissue with TNFRSF14 antibody at 10 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92956
Other Accession Q92956, 13878821
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 20, 22, 29, 31 kDa

Observed: 23 kDa
Application Notes TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 1 µg/mL. For immunofluorescence start at 10 µg/mL.
Additional Information
Gene ID 8764
Other Names TNFRSF14 Antibody: TR2, ATAR, HVEA, HVEM, CD270, LIGHTR, UNQ329/PRO509, Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Target/Specificity TNFRSF14; Multiple isoforms of TNFRSF14 are known to exist.
Reconstitution & Storage TNFRSF14 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTNFRSF14 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HVEA, HVEM
Function Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed, with the highest expression in lung, spleen and thymus
Research Areas
Citations (0)

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TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-κB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.


Montgomery RI, Warner MS, Lum BJ, et al. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 1996; 87:427-36.
Montgomery RI, Warner MS, Lum BJ, et al. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 1996; 87:427-36.
Marsters SA, Ayres TM, Skubatch M, et al. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-κB and AP-1. J. Biol. Chem. 1997; 272:14029-32.
Mauri DN, Ebner R, Montgomery RI, et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 1998; 8:21-30.

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$ 310.00
Cat# ASC10410
(40 western blots)
Availability: 5-7days
Bulk Size
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