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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRPC6 Antibody   

TRPC6 Antibody

  • WB - TRPC6 Antibody ASC10450
    Western blot analysis of TRPC6 in mouse lung tissue lysate with TRPC6 antibody at (A) 0.5, (B) 1 and (C) 2 µg/mL.
  • IHC - TRPC6 Antibody ASC10450
    Immunohistochemistry of TRPC6 in mouse lung tissue with TRPC6 antibody at 10 µg/mL.
  • IF - TRPC6 Antibody ASC10450
    Immunofluorescence of TRPC6 in Mouse Lung cells with TRPC6 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y210
Other Accession AAH93658, 62739910
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 100, 102 kDa

Observed: 93 kDa
Application Notes TRPC6 antibody can be used for the detection of TRPC6 by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 7225
Other Names TRPC6 Antibody: TRP6, FSGS2, TRP6, Short transient receptor potential channel 6, Transient receptor protein 6, TrpC6, transient receptor potential cation channel, subfamily C, member 6
Target/Specificity TRPC6; This antibody may cross-react with TRPC3.
Reconstitution & Storage TRPC6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTRPC6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPC6
Synonyms TRP6
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm
Research Areas
Citations (0)

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TRPC6 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.


Contell C, Birnbaumer V, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002; 9:229-31.
Dietrich A, Kalwa H, Rost BR, et al. The diacylglycerol-sensitive TRPC6/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch. 2005; 451:72-80.
Trebak M, Vazquez G, Bird GSJ, et al. The TRPC6/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61

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$ 310.00
Cat# ASC10450
(40 western blots)
Availability: 5-7days
Bulk Size
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