|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_057672, 7706123|
|Calculated MW||Predicted: 16 kDa |
Observed: 15 kDa
|Application Notes||Neuritin antibody can be used for detection of Neuritin by Western blot at 5 and 10 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Other Names||Neuritin Antibody: NRN, dJ380B8.2, NRN, Neuritin, neuritin 1|
|Reconstitution & Storage||Neuritin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||Neuritin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse|
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Provided below are standard protocols that you may find useful for product applications.
Neuritin Antibody: As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.
Li Z and Sheng M. Some assembly required: the development of neuronal synapses. Nat. Rev. Mol. Cell Biol. 2003; 4:833-41.
Naeve GS, Ramakrishnan M, Kramer R, et al. Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc. Natl. Acad. Sci. USA 1997; 94:2648-53.
Marron TU, Guerini V, Rusmini P, et al. Androgen-induced neurite outgrowth is mediated by neuritin in motor neurons. J. Neurochem. 2005; 92:10-20.
Di Giovanni S, De Biase A, Yakovlev A, et al. In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury. J. Biol. Chem. 2005; 280:2084-91.
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