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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Neurotrypsin Antibody   

Neurotrypsin Antibody

  • WB - Neurotrypsin Antibody ASC10525
    Western blot analysis of neurotrypsin in 3T3 cell lysate with neurotrypsin antibody at (A) 0.25 and (B) 0.5 µg/mL.
  • IHC - Neurotrypsin Antibody ASC10525
    Immunohistochemistry of Neurotrypsin in human brain tissue with Neurotrypsin antibody at 2.5 µg/mL.
  • IF - Neurotrypsin Antibody ASC10525
    Immunofluorescence of Neurotrypsin in Human Brain cells with Neurotrypsin antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P56730
Other Accession CAA04816, 2661424
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 96 kDa

Observed: 96 kDa
Application Notes Neurotrypsin antibody can be used for detection of neurotrypsin by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 8492
Other Names Neurotrypsin Antibody: MRT1, BSSP3, BSSP-3, Neurotrypsin, Leydin, protease, serine, 12 (neurotrypsin, motopsin)
Target/Specificity PRSS12;
Reconstitution & Storage Neurotrypsin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNeurotrypsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRSS12
Function Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
Cellular Location Secreted.
Tissue Location Brain and Leydig cells of the testis.
Research Areas
Citations (0)

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Neurotrypsin Antibody: Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.


Gschwend TP, Krueger SR, Kozlov SV, et al. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol. Cell. Neurosci.1997; 9:207-19.
Molinari F, Rio M, Meskanaite V, et al. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science2002; 1779-81.
Mitsui S, Yamaguchi N, Osako Y, et al. Enzymatic properties and localization of motopsin (PRSS12), a protease who absence causes mental retardation. Brain Res.2007; 1136:1-12.

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$ 310.00
Cat# ASC10525
(40 western blots)
Availability: 5-7days
Bulk Size
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