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NPAS3 Antibody

  • WB - NPAS3 Antibody ASC10526
    Western blot analysis of NPAS3 in SK-N-SH cell lysate with NPAS3 antibody at (A) 0.5, (B) 1 and (C) 2 µg/mL.
  • IHC - NPAS3 Antibody ASC10526
    Immunohistochemistry of NPAS3 in human brain tissue with NPAS3 antibody at 5 µg/mL.
  • IF - NPAS3 Antibody ASC10526
    Immunofluorescence of NPAS3 in human brain tissue with NPAS3 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IXF0
Other Accession Q8IXF0, 38604888
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 100805 Da
Application Notes NPAS3 antibody can be used for detection of NPAS3 by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 64067
Other Names NPAS3 Antibody: MOP6, PASD6, bHLHe12, BHLHE12, MOP6, Neuronal PAS domain-containing protein 3, Basic-helix-loop-helix-PAS protein MOP6, Neuronal PAS3, neuronal PAS domain protein 3
Target/Specificity NPAS3;
Reconstitution & Storage NPAS3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsNPAS3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPAS3
Synonyms BHLHE12, MOP6, PASD6
Function May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:12746393}
Tissue Location Ubiquitously expressed in the adult brain.
Research Areas
Citations (0)

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NPAS3 Antibody: Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.


Brunskill EW, Witte DP, Shreiner AB et al. Characterization of npas3, a novel basic helix-loop-helix PAS gene expressed in the developing mouse nervous system. Mech. Dev.1999; 88:237-41.
Kamnasaran D, Muir WJ, Ferguson-Smith MA, et al. Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. J. Med. Genet.40:325-32.
Brunskill EW, Ehrman LA, Williams MT, et al. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Euro. J. Neurosci.2005; 22:1265-76.

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$ 330.00
Cat# ASC10526
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