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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KIF5 Antibody   

KIF5 Antibody

  • WB - KIF5 Antibody ASC10566
    Western blot analysis of KIF5 in K562 cell lysate with KIF5 antibody at (A) 0.5 and (B) 1 µg/mL.
  • ICC - KIF5 Antibody ASC10566
    Immunocytochemistry of KIF5 in K562 cells with KIF5 antibody at 5 µg/mL.
  • IF - KIF5 Antibody ASC10566
    Immunofluorescence of KIF5 in K562 cells with KIF5 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12840
Other Accession Q12840, 143811412
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 105, 114 kDa

Observed: 118 kDa
Application Notes KIF5 antibody can be used for detection of KIF5 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 3798
Target/Specificity KIF5A; KIF5 has at least three known isoforms; this antibody recognizes all three.
Reconstitution & Storage KIF5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsKIF5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIF5A
Synonyms NKHC1
Function Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).
Cellular Location Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region
Tissue Location Distributed throughout the CNS but is highly enriched in subsets of neurons
Research Areas
Citations (0)

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KIF5 Antibody: The kinesin superfamily proteins (KIFs) are microtubule-dependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. Mutations in one of the three isoforms of KIF5 (KIF5A) are thought to be involved in hereditary spastic paraplegias.


Hirokawa N. mRNA transport in dendrites: RNA granules, motors and tracks. J. Neurosci. 2006; 26:7139-42.
Niclas J, Navone F, Hom-Booher N, et al. Cloning and localization of a conventional KIF5 motor expressed exclusively in neurons. Neuron 1994; 12:1059-72.
Fichera M, Lo Giudice M, Falco M, et al. Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia. Neurology 2004; 63:1108-10.

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$ 310.00
Cat# ASC10566
(40 western blots)
Availability: 5-7days
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