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Grik1 Antibody

  • WB - Grik1 Antibody ASC10606
    Western blot analysis of Grik1 in P815 cell lysate with Grik1 antibody at (A) 0.5, (B) 1 and (C) 2 µg/mL.
  • IHC - Grik1 Antibody ASC10606
    Immunohistochemical staining of human brain tissue using Grik1 antibody at 2.5 µg/mL.
  • IF - Grik1 Antibody ASC10606
    Immunofluorescence of Grik1 in Human Brain cells with Grik1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P39086
Other Accession P39086, 729597
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 103981 Da
Application Notes Grik1 antibody can be used for detection of Grik1 by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 2897
Target/Specificity GRIK1;
Reconstitution & Storage Grik1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsGrik1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIK1
Synonyms GLUR5
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
Tissue Location Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus
Research Areas
Citations (0)

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Grik1 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.


Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.
Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
Bureau I, Dieudonne S, Coussen F, et al. Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J. Neurosci.1999; 19:653-63.
Christensen JK, Paternain AV, Selak S, et al. A mosaic of functional kainate receptors in hippocampal interneurons. J. Neurosci.2004; 24:8986-93.

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$ 310.00
Cat# ASC10606
(40 western blots)
Availability: 5-7days
Bulk Size
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