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Grik4 Antibody

  • WB - Grik4 Antibody ASC10611
    Western blot analysis of Grik4 in Rat brain tissue lysate with Grik4 antibody at (A) 0.5, (B) 1 and (C) 2 µg/mL.
  • IHC - Grik4 Antibody ASC10611
    Immunohistochemical staining of human brain tissue using Grik4 antibody at 2.5 µg/mL.
  • IF - Grik4 Antibody ASC10611
    Immunofluorescence of Grik4 in Human Brain cells with Grik4 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16099
Other Accession Q16099, 209572625
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 107246 Da
Application Notes Grik4 antibody can be used for detection of Grik4 by Western blot at 0.5 - 2 µg/mL. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 2900
Target/Specificity GRIK4;
Reconstitution & Storage Grik4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsGrik4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRIK4
Synonyms GRIK
Function Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Grik4 Antibody: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder.


Tanaka K. Functions of glutamate transporters in the brain. Neurosci. Res.2000; 37:15-9.
Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.
Mayer ML. GRIK4 and the Kainate Receptor. Am. J. Psychiatry2007; 164:1148.
Pickard BS, Malloy MP, Christoforou A, et al. Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol. Psychiatry2006; 11:847-57.

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$ 310.00
Cat# ASC10611
(40 western blots)
Availability: 5-7days
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