Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Cathelicidin Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P49913 |
| Other Accession | NP_004336, 820 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 19 kDa Observed: 18 kDa |
| Application Notes | Cathelicidin antibody can be used for detection of Cathelicidin by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. |
| Gene ID | 820 |
|---|---|
| Target/Specificity | Cathelicidin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Cathelicidin. The immunogen is located within amino acids 50 - 100 of Cathelicidin. |
| Reconstitution & Storage | Cathelicidin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | Cathelicidin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAMP (HGNC:1472) |
|---|---|
| Function | Antimicrobial protein that is an integral component of the innate immune system (PubMed:22879591, PubMed:16637646, PubMed:18818205, PubMed:9736536, PubMed:14978112). Binds to bacterial lipopolysaccharides (LPS) (PubMed:16637646, PubMed:18818205). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591). Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin (PubMed:14978112). The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) (PubMed:9736536). |
| Cellular Location | Secreted. Vesicle. Note=Stored as pro-peptide in granules and phagolysosomes of neutrophils (PubMed:9736536, PubMed:7529412). Secreted in sweat onto skin (PubMed:14978112). |
| Tissue Location | Expressed in neutrophilic granulocytes (at protein level) (PubMed:7890387, PubMed:8946956, PubMed:9736536, PubMed:7529412, PubMed:7615076, PubMed:8681941). Expressed in bone marrow (PubMed:7890387). [Antibacterial peptide FALL-39]: Expressed in bone marrow and testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Cathelicidin Antibody: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
References
Zaiou M and Gallo RL. Cathelicidins, essential gene-encoded mammalian antibiotics. J. Mol. Med. 2002; 80:549-61.
Agerberth B, Gunne H, Odeberg J, et al. FALL-39, a Putative Human Peptide Antibiotic, is Cysteine-Free and Expressed in Bone Marrow and Testis. Proc. Natl. Acad. Sci. USA 1995; 92:195-9.
Nizet V, Ohtake T, Lauthe X, et al. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001; 414:454-7.
Koczulla R, von Degenfeld G, Kupatt C, et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 2003; 111:1665-72.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
