|Application ||WB, E|
|Other Accession||AAH99718, 71043465|
|Calculated MW||50270 Da|
|Application Notes||Unc93a antibody can be used for the detection of Unc93a by Western blot at 0.5 - 1 µg/mL.|
|Target/Specificity||UNC93A; Two isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93b.|
|Reconstitution & Storage||Unc93a antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||Unc93a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in testis, small intestine, spleen, prostate and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
Unc93a Antibody: Unc93a, a human homolog of the C. elegans Unc93 gene, was initially identified by the sequencing of chromosome 6q27 at D6S193 as loss at this region correlated with sporadic ovarian cancer. Further analysis however, showed no tumor suppressor role for Unc93a. Unlike Unc93b, another homolog of the C. elegans Unc93 gene that is crucial for Toll-like receptor (TLR) signaling, the function of Unc93a is unknown. It is expressed in testis, small intestine, spleen, prostate and ovary.
Liu Y, Dodds P, Emilion G, et al. The human homolog of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer. BioMed Central Genetics2002; 3:20.
Massey DC and Parkes M. Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease. Autophagy2007; 3:649-51.
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