|Application ||WB, E|
|Other Accession||CAD90042, 30348608|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||92909 Da|
|Application Notes||UROP11 antibody can be used for detection of UROP11 by Western blot at 1 - 2 µg/mL. Despite its predicted molecular weight, UROP11 often migrates at a much higher apparent size in SDS-PAGE.|
|Reconstitution & Storage||UROP11 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||UROP11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-AAP (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Nucleus|
|Tissue Location||Isoform 3 is expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
UROP11 Antibody: Upregulated obese product 11 (UROP11) was isolated from subtractive library for mouse hypothalamus. It is detected in numerous tissues and is upregulated in the hypothalamus and adipocytes in obese mice. UROP11 is also observed in human neural and lymphoid tissues; its expression appears to be regulated by the level of lymphoid activation. Urop11 expression is strongly upregulated both in vivo in mouse hypothalamus and in vitro in mouse neural cell lines after treatment with leptin, indicating Urop11 is a target of leptin activity and thus may play a role in obesity.
Verlaeten O, Casery C, Cavagna S, et al. Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. J. Mol. Endocrinol.2007; 38:3-17.
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