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PRTFDC1 Antibody

  • WB - PRTFDC1 Antibody ASC10754
    Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 µg/mL in the (A) absence and (B) presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NRG1
Other Accession NP_064585, 9910262
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 25674 Da
Application Notes PRTFDC1 antibody can be used for detection of PRTFDC1 by Western blot at 1 µg/mL.
Additional Information
Gene ID 56952
Target/Specificity PRTFDC1;
Reconstitution & Storage PRTFDC1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsPRTFDC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HHGP
Function Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
Citations (0)

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PRTFDC1 Antibody: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.


Nicklas JA. Pseudogenes of the human HPRT1 gene. Environ. Mol. Mutagen2006; 47:212-8.
Keebaugh AC, Sullivan RT, NISC Comparative Sequencing Program, et al. Gene duplication and inactivation in the HPRT gene family. Genomics2007; 89:134-42.
Cai LY, Abe M, Izumi S, et al. Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci.2007; 80:1458-65.
Suzuki E, Imoto I, Pimkhaokham A, et al. PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinoma by aberrant promoter hypermethylation. Oncogene2007; 26:7921-32.

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$ 330.00
Cat# ASC10754
Availability: 5-7days
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