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MettL7A Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H8H3 |
| Other Accession | NP_054752, 89145417 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 28319 Da |
| Application Notes | MettL7A antibody can be used for detection of MettL7A by Western blot at 2 µg/mL. |
| Gene ID | 25840 |
|---|---|
| Target/Specificity | METTL7A; At least two isoforms of MettL7A are known to exist. This MettL7A antibody is predicted to not cross-react with MettL7B. |
| Reconstitution & Storage | MettL7A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Precautions | MettL7A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMT1A {ECO:0000303|PubMed:37137720, ECO:0000312|HGNC:HGNC:24550} |
|---|---|
| Function | Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol- containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358). |
| Cellular Location | Lipid droplet. Endoplasmic reticulum. Membrane. Microsome Cytoplasm, cytosol. Note=Inserted in the ER membrane and migrates from the inserted site to lipid droplet |
| Tissue Location | Expressed in the liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MettL7A Antibody: MettL7A belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.
References
Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70.
Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell1992; 69:915-26.
Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics1994; 3:1487-95.
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