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TOM70 Antibody

  • WB - TOM70 Antibody ASC10822
    Western blot analysis of TOM70 in rat brain tissue lysate with TOM70 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - TOM70 Antibody ASC10822
    Immunohistochemistry of TOM70 in mouse brain tissue with TOM70 antibody at 2.5 µg/mL.
  • IF - TOM70 Antibody ASC10822
    Immunofluorescence of TOM70 in Mouse Brain cells with TOM70 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O94826
Other Accession NP_055635, 54607135
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 67455 Da
Application Notes TOM70 antibody can be used for detection of TOM70 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 9868
Target/Specificity TOMM70A;
Reconstitution & Storage TOM70 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTOM70 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOMM70A
Synonyms KIAA0719, TOM70
Function Receptor that accelerates the import of all mitochondrial precursor proteins.
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein
Research Areas
Citations (0)

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TOM70 Antibody: The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.


Kutik S, Guiard B, Meyer HE, et al. Cooperation of translocase complexes in mitochondrial protein import. J. Cell Biol.2007; 179:585-91.
Young JC, Hoogenraad NJ, and Hartl FU. Molecular chaperones Hsp90 and Hsc70 deliver preproteins to the mitochondrial import receptor Tom70. Cell2003; 112:41-50.

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$ 310.00
Cat# ASC10822
(40 western blots)
Availability: 5-7days
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