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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TTBK1 Antibody   

TTBK1 Antibody

  • WB - TTBK1 Antibody ASC10846
    Western blot analysis of TTBK1 in Jurkat lysate with TTBK1 antibody at 1 µg/mL.
  • IHC - TTBK1 Antibody ASC10846
    Immunohistochemistry of TTBK1 in mouse brain tissue with TTBK1 antibody at 2.5 µg/mL.
  • IF - TTBK1 Antibody ASC10846
    Immunofluorescence of TTBK1 in Human Brain tissue with TTBK1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5TCY1
Other Accession Q5TCY1, 97203020
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 145, 151 kDa

Observed: 140 kDa
Application Notes TTBK1 antibody can be used for detection of TTBK1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 84630
Target/Specificity TTBK1; Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
Reconstitution & Storage TTBK1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTTBK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTBK1
Synonyms BDTK, KIAA1855
Function Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Cellular Location Cytoplasm.
Tissue Location Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.
Research Areas
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TTBK1 Antibody: Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients.


Sato S, Cerny RL, Bueschner JL, et al. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J. Neurochem. 2006; 98:1573-84.
Sato S, Xu J, Okuyama S, et al. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J. Neurosci. 2008; 28:14511-21.

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$ 310.00
Cat# ASC10846
(40 western blots)
Availability: 5-7days
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