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CDIP Antibody

  • WB - CDIP Antibody ASC10859
    Western blot analysis of CDIP in human brain lysate with CDIP antibody at (A) 0.25 and (B) 0.5 µg/mL.
  • IHC - CDIP Antibody ASC10859
    Immunohistochemistry of CDIP in mouse brain tissue with CDIP antibody at 2.5 µg/mL.
  • IF - CDIP Antibody ASC10859
    Immunofluorescence of CDIP1 in mouse brain tissue with CDIP1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H305
Other Accession NP_037531, 118344450
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 21892 Da
Application Notes CDIP antibody can be used for detection of CDIP by Western blot at 0.25 - 0.5 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 29965
Target/Specificity C16orf5;
Reconstitution & Storage CDIP antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsCDIP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDIP1
Synonyms C16orf5, CDIP, LITAFL
Function Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
Tissue Location Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver Weakly or not expressed in placenta and lung
Research Areas
Citations (0)

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CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.


Guimaraes DP and Hainaut P. TP53: a key gene in human cancer. Biochimie2002; 84:83-93.
Brown L, Ongusaha PP, Kim H-H, et al. CDIP, a novel pro-apoptotic gene, regulates TNFa-mediated apoptosis in a p53-dependent manner. EMBO J.2007; 26:3410-22.

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$ 330.00
Cat# ASC10859
Availability: 5-7days
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