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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MATN1 Antibody   

MATN1 Antibody

     
  • WB - MATN1 Antibody ASC10886
    Western blot analysis of MATN1 in rat liver tissue lysate with MATN1 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - MATN1 Antibody ASC10886
    Immunohistochemistry of MATN1 in human liver tissue with MATN1 antibody at 5 µg/mL.
  • IF - MATN1 Antibody ASC10886
    Immunofluorescence of MATN1 in Human Liver cells with MATN1 antibody at 20 µg/mL.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P21941
Other Accession NP_002370, 4505111
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes MATN1 antibody can be used for detection of MATN1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 4146
Target/Specificity MATN1;
Reconstitution & Storage MATN1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsMATN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MATN1
Synonyms CMP, CRTM
Function Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.
Cellular Location Secreted, extracellular space, extracellular matrix EMBL; M55682; AAB38702.1; -; Genomic_DNA EMBL; M55675; AAB38702.1; JOINED; Genomic_DNA EMBL; M55676; AAB38702.1; JOINED; Genomic_DNA EMBL; M55677; AAB38702.1; JOINED; Genomic_DNA EMBL; M55679; AAB38702.1; JOINED; Genomic_DNA EMBL; M55680; AAB38702.1; JOINED; Genomic_DNA EMBL; M55681; AAB38702.1; JOINED; Genomic_DNA EMBL; M55683; AAA63904.1; -; mRNA EMBL; AK312949; BAG35790.1; -; mRNA EMBL; AL137857; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS336.1; - PIR; A37979; A37979 RefSeq; NP_002370.1; NM_002379.3 UniGene; Hs.150366; - ProteinModelPortal; P21941; - BioGrid; 110316; 4 STRING; 9606.ENSP00000362870; - iPTMnet; P21941; - PhosphoSitePlus; P21941; - BioMuta; MATN1; - DMDM; 115556; - PaxDb; P21941; - PeptideAtlas; P21941; - PRIDE; P21941; - ProteomicsDB; 53943; - DNASU; 4146; - Ensembl; ENST00000373765; ENSP00000362870; ENSG00000162510 GeneID; 4146; - KEGG; hsa:4146; - UCSC; uc001brz.4; human CTD; 4146; - DisGeNET; 4146; - EuPathDB; HostDB:ENSG00000162510.5; - GeneCards; MATN1; - H-InvDB; HIX0000347; - H-InvDB; HIX0028643; - H-InvDB; HIX0029177; - HGNC; HGNC:6907; MATN1 HPA; HPA028580; - MIM; 115437; gene neXtProt; NX_P21941; - OpenTargets; ENSG00000162510; - PharmGKB; PA30650; - eggNOG; ENOG410IR75; Eukaryota eggNOG; ENOG410XSCQ; LUCA GeneTree; ENSGT00920000148956; - HOGENOM; HOG000263415; - HOVERGEN; HBG056906; - InParanoid; P21941; - OMA; YTCACHE; - OrthoDB; EOG091G04O4; - PhylomeDB; P21941; - TreeFam; TF330078; - Reactome; R-HSA-3000178; ECM proteoglycans GeneWiki; MATN1; - GenomeRNAi; 4146; - PRO; PR:P21941; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000162510; - CleanEx; HS_MATN1; - Genevisible; P21941; HS GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro GO; GO:0031012; C:extracellular matrix; TAS:ProtInc GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0005509; F:calcium ion binding; IEA:InterPro GO; GO:0005201; F:extracellular matrix structural constituent; TAS:ProtInc GO; GO:0030198; P:extracellular matrix organization; TAS:Reactome GO; GO:0003429; P:growth plate cartilage chondrocyte morphogenesis; IEA:Ensembl GO; GO:0065003; P:protein-containing complex assembly; TAS:ProtInc GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl Gene3D; 1.20.5.30; -; 1 Gene3D; 3.40.50.410; -; 2 InterPro; IPR001881; EGF-like_Ca-bd_dom InterPro; IPR013032; EGF-like_CS InterPro; IPR000742; EGF-like_dom InterPro; IPR030751; Matrilin-1 InterPro; IPR036337; Matrilin_cc_sf InterPro; IPR019466; Matrilin_coiled-coil_trimer InterPro; IPR002035; VWF_A InterPro; IPR036465; vWFA_dom_sf PANTHER; PTHR44857; PTHR44857; 1 Pfam; PF10393; Matrilin_ccoil; 1 Pfam; PF00092; VWA; 2 SMART; SM00181; EGF; 1 SMART; SM00179; EGF_CA; 1 SMART; SM01279; Matrilin_ccoil; 1 SMART; SM00327; VWA; 2 SUPFAM; SSF53300; SSF53300; 2 SUPFAM; SSF58002; SSF58002; 1 PROSITE; PS01186; EGF_2; 1 PROSITE; PS50234; VWFA; 2 1: Evidence at protein level; Coiled coil; Complete proteome; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Reference proteome; Repeat; Secreted; Signal SIGNAL 1 22 CHAIN 23 496 Cartilage matrix protein /FTId=PRO_0000007495 DOMAIN 23 222 VWFA 1. {ECO:0000255|PROSITE- ProRule:PRU00219} DOMAIN 223 263 EGF-like DOMAIN 264 453 VWFA 2. {ECO:0000255|PROSITE- ProRule:PRU00219} COILED 467 495 CARBOHYD 76 76 N-linked (GlcNAc...) asparagine DISULFID 35 221 DISULFID 227 238 DISULFID 234 247 DISULFID 249 262 DISULFID 265 452 CONFLICT 291 291 F -> L (in Ref. 1; AAA63904) SEQUENCE 496 AA; 53701 MW; 2D880A8114C7940F CRC64; MRVLSGTSLM LCSLLLLLQA LCSPGLAPQS RGHLCRTRPT DLVFVVDSSR SVRPVEFEKV KVFLSQVIES LDVGPNATRV GMVNYASTVK QEFSLRAHVS KAALLQAVRR IQPLSTGTMT GLAIQFAITK AFGDAEGGRS RSPDISKVVI VVTDGRPQDS VQDVSARARA SGVELFAIGV GSVDKATLRQ IASEPQDEHV DYVESYSVIE KLSRKFQEAF CVVSDLCATG DHDCEQVCIS SPGSYTCACH EGFTLNSDGK TCNVCSGGGG SSATDLVFLI DGSKSVRPEN FELVKKFISQ IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK GTMTGAALKY LIDNSFTVSS GARPGAQKVG IVFTDGRSQD YINDAAKKAK DLGFKMFAVG VGNAVEDELR EIASEPVAEH YFYTADFKTI NQIGKKLQKK ICVEEDPCAC ESLVKFQAKV EGLLQALTRK LEAVSKRLAI LENTVV
Research Areas
Citations (0)

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Background

MATN1 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN1 is composed of two Willebrand Factor A (vWFA) domains separated by one EGF-like domain, whereas MATN3 is composed of a single N-terminal vWFA domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that the MATN1 promoter region was associated with both susceptibility and disease progression in Adolescent idiopathic scoliosis.

References

Pei M, Luo J, and Chen Q. Enhancing and maintaining matrilins. Osteoarthritis Cartilage2008; 16:1110-7.
Frank S, Schulthess T, Landwehr R, et al. Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. J. Biol. Chem.2002; 277:19071-9.
Chen Q, Johnson DM, Haudenschild DR, et al. Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation. Dev. Biol.1995; 172:293-306.
Stokes DG, Liu G, Coimbra IB, et al. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum2002; 46:404-19.

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Cat# ASC10886
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