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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGS21 Antibody   

RGS21 Antibody

  • WB - RGS21 Antibody ASC10918
    Western blot analysis of RGS21 in HepG2 cell lysate with RGS21 antibody at 0.5 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • ICC - RGS21 Antibody ASC10918
    Immunocytochemistry of RGS21 in HepG2 cells with RGS21 antibody at 2.5 µg/mL.
  • IF - RGS21 Antibody ASC10918
    Immunofluorescence of RGS21 in HepG2 cells with RGS21 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q2M5E4
Other Accession NP_001034241, 85540441
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application Notes RGS21 antibody can be used for detection of RGS21 by Western blot at 0.5 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 431704
Target/Specificity RGS21;
Reconstitution & Storage RGS21 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsRGS21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS21
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Tissue Location Expressed ubiquitously. EMBL; AY643711; AAT64913.1; -; mRNA CCDS; CCDS41448.1; - RefSeq; NP_001034241.1; NM_001039152.3 UniGene; Hs.558673; - ProteinModelPortal; Q2M5E4; - SMR; Q2M5E4; - STRING; 9606.ENSP00000428343; - iPTMnet; Q2M5E4; - PhosphoSitePlus; Q2M5E4; - BioMuta; RGS21; - DMDM; 121941516; - PaxDb; Q2M5E4; - PeptideAtlas; Q2M5E4; - PRIDE; Q2M5E4; - ProteomicsDB; 61388; - DNASU; 431704; - Ensembl; ENST00000417209; ENSP00000428343; ENSG00000253148 GeneID; 431704; - KEGG; hsa:431704; - UCSC; uc001gsh.4; human CTD; 431704; - DisGeNET; 431704; - EuPathDB; HostDB:ENSG00000253148.1; - GeneCards; RGS21; - HGNC; HGNC:26839; RGS21 HPA; HPA052843; - MIM; 612407; gene neXtProt; NX_Q2M5E4; - OpenTargets; ENSG00000253148; - PharmGKB; PA134875582; - eggNOG; KOG3589; Eukaryota eggNOG; ENOG410YMJD; LUCA GeneTree; ENSGT00760000118903; - HOGENOM; HOG000233513; - HOVERGEN; HBG013233; - InParanoid; Q2M5E4; - KO; K16449; - OMA; CCFYRSP; - OrthoDB; EOG091G0BDG; - PhylomeDB; Q2M5E4; - TreeFam; TF315837; - Reactome; R-HSA-416476; G alpha (q) signalling events Reactome; R-HSA-418594; G alpha (i) signalling events ChiTaRS; RGS21; human GenomeRNAi; 431704; - PRO; PR:Q2M5E4; - Proteomes; UP000005640; Chromosome 1 CleanEx; HS_RGS21; - GO; GO:0005737; C:cytoplasm; IBA:GO_Central GO; GO:0005886; C:plasma membrane; IBA:GO_Central GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW Gene3D;; -; 2 InterPro; IPR016137; RGS InterPro; IPR036305; RGS_sf InterPro; IPR024066; RGS_subdom1/3 Pfam; PF00615; RGS; 1 PRINTS; PR01301; RGSPROTEIN SMART; SM00315; RGS; 1 SUPFAM; SSF48097; SSF48097; 1 PROSITE; PS50132; RGS; 1 2: Evidence at transcript level; Complete proteome; Reference proteome; Signal transduction inhibitor CHAIN 1 152 Regulator of G-protein signaling 21 /FTId=PRO_0000271375 DOMAIN 21 137 RGS. {ECO:0000255|PROSITE- ProRule:PRU00171} SEQUENCE 152 AA; 17671 MW; D9EF097E89CA9731 CRC64; MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF WLACEDFKKT KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI AEPTLKCFDE AQKLIYCLMA KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP FL
Research Areas
Citations (0)

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RGS21 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.


De Vries L, Mousli M, Wurmser A, et al. GAIP, a protein that specifically interacts with the G protein G alpha i3, is a member of a protein family with a highly conserved core domain. Proc. Natl. Acad. Sci. USA1995; 92:11916-20.
Berman DM, Wilkie TM, and Gilman AG. GAIP and RGS4 are GTP-ase activating proteins for the Gi subfamily of G protein alpha subunits. Cell1996; 86:445-52.
von Bucholtz L, Elischer A, Tareilus E, et al. RGS21 is a novel regulator of G protein signalling selectively expressed in subpopulations of taste bud cells. Eur. J. Neurosci.2004; 19:1535-44.
Li X, Chen L, Ji C, et al. Isolation and expression pattern of RGS21 gene, a novel RGS member. Acta Biochim. Pol.2005; 52:943-6.

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$ 330.00
Cat# ASC10918
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